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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Bastos,M. F. (1) Cavalcante,D. P. (1) Chacur,M. (1) Cury,Y. (1) Ferreira,J. (1) Gutiérrez,J.M. (1) Pelizon,A. C. (1) Peres,C. M. (1) Picolo,G. (1) Sartori,A. (1) Teixeira,C.F.P. (1) Mais... Palavra-chave Bothrops jararaca venom (2) Edema (2) Antivenom (1) Bothrops asper venom (1) ELISA (1) Hyperalgesia (1) Neutralization (1) Ovine antiserum (1) Venom levels (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Assessment of the neutralizing potency of ovine antivenom in a swiss mice model of Bothrops jararaca envenoming J. Venom. Anim. Toxins incl. Trop. Dis. Ferreira,J.; Bastos,M. F.; Pelizon,A. C.; Peres,C. M.; Cavalcante,D. P.; Sartori,A.. Alternative sources of anti-ophidic serum are being investigated due to the secondary effects associated with types I and II hypersensitivity reactions. In the present study we raised and evaluated the protective effect of an ovine antibothropic serum in a Swiss mice envenoming model. Ovine antiserum was obtained by immunization with seven increasing doses of bothropic venom associated with adjuvants. The neutralizing ability was tested by the lethal activity (2 LD50) neutralization and serum and splenic venom levels after antivenom administration to experimentally envenomed mice. The antiserum effect on local edema was also tested by injection of venom/antivenom mixtures into the mice footpads. Ovine antiserum neutralized lethal activity and also... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops jararaca venom; Ovine antiserum; Venom levels; Edema; ELISA. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300010 Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms BJMBR Picolo,G.; Chacur,M.; Gutiérrez,J.M.; Teixeira,C.F.P.; Cury,Y.. Neutralization of hyperalgesia induced by Bothrops jararaca and B. asper venoms was studied in rats using bothropic antivenom produced at Instituto Butantan (AVIB, 1 ml neutralizes 5 mg B. jararaca venom) and polyvalent antivenom produced at Instituto Clodomiro Picado (AVCP, 1 ml neutralizes 2.5 mg B. aspar venom). The intraplantar injection of B. jararaca and B. asper venoms caused hyperalgesia, which peaked 1 and 2 h after injection, respectively. Both venoms also induced edema with a similar time course. When neutralization assays involving the independent injection of venom and antivenom were performed, the hyperalgesia induced by B. jararaca venom was neutralized only when bothropic antivenom was administered iv 15 min before venom injection, whereas... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops jararaca venom; Bothrops asper venom; Hyperalgesia; Edema; Antivenom; Neutralization. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000016 Registros recuperados: 2 Primeira ... 1 ... Última

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